| Compound | Day | ||||
| 1 | 5 | 8 | 12 | 14 | |
| Control 0 mg/kg | |||||
| Mean gross body weight (g) | 25.7 | 26.4 | 27.6 | 26.7 | 26.8 |
| Mean gross body weight change (g) | +0.7 | +1.9 | +1.0 | +1.1 | |
| Mean gross body weight change (%) | 3 | 7 | 4 | 4 | |
| DOX orotate 9.75 mg/kg | |||||
| Mean gross body weight (g) | 27.6 | 27.0 | 26.9 | 24.1 | 22.1 |
| Mean gross body weight change (g) | −0.6 | −0.7 | −3.5 | −5.5 | |
| Mean gross body weight change (%) | −2 | −3 | −13 | −20 | |
| Liposomal doxorubicin8.0 mg/kg | |||||
| Mean gross body weight (g) | 26.4 | 26.1 | 25.8 | 24.6 | 23.6 |
| Mean gross body weight change (g) | −0.3 | −0.6 | −1.8 | −2.8 | |
| Mean gross body weight change (%) | −1 | −2 | −7 | −11 | |
| DOX 8.0 mg/kg | |||||
| Mean gross body weight (g) | 26.1 | 25.4 | 24.5 | 21.5 | 19.3 |
| Mean gross body weight change (g) | −0.7 | −1.6 | −4.6 | −6.8 | |
| Mean gross body weight change (%) | −3 | −6 | −18 | −26 | |